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Related Experiment Video

Updated: May 6, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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Could Autism Spectrum Disorder Be Associated With Craniosynostosis?

Megan E H Still1, Amelia Alberts2, Prianca Nagda2

  • 1Department of Neurosurgery, University of Florida.

The Journal of Craniofacial Surgery
|May 5, 2026
PubMed
Summary

This study found no significant differences in skull measurements between children with autism spectrum disorder (ASD) and controls. Craniosynostosis patients with ASD also showed no distinct cranial vault measurements, suggesting incidental diagnoses.

Keywords:
ASDCraniosynostosisautismneurosurgerypediatricssutures

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Area of Science:

  • Pediatric neurosurgery
  • Developmental neuroscience
  • Medical imaging

Background:

  • Craniosynostosis is a pediatric condition with varied symptoms, from cosmetic issues to intracranial hypertension.
  • The relationship between craniosynostosis and neurodevelopmental disorders like autism spectrum disorder (ASD) is not well understood.

Purpose of the Study:

  • To compare skull vault measurements in pediatric patients with ASD and craniosynostosis.
  • To identify potential abnormal findings in ASD patients related to synostotic changes.

Main Methods:

  • Retrospective review of pediatric head CT scans.
  • Comparison of cranial vault measurements between groups: craniosynostosis, ASD, and controls.
  • Analysis of sagittal and metopic craniosynostosis cases.

Main Results:

  • No significant differences in cranial vault measurements were found between patients with ASD and controls.
  • Patients with craniosynostosis showed significant differences in specific measurements compared to controls.
  • No significant measurement differences were observed between craniosynostosis patients with and without ASD.

Conclusions:

  • Cranial vault measurements do not significantly differ between patients with ASD and controls.
  • Co-occurring ASD in craniosynostosis patients did not yield significantly different cranial measurements.
  • The co-occurrence of ASD and craniosynostosis is likely incidental rather than causal.