A Palladium(IV) Amido Alkyl System Relevant to C(sp3)-N Bond Formation
Haobin Li1, Rui Feng1,2, Xiyao Cai1
1Department of Chemistry, Capital Normal University, Beijing 100048, China.
None:
Despite remarkable progress in Pd-catalyzed synthesis of N-containing molecules, well-defined Pd(IV) amido alkyl species, which are highly relevant to C(sp3)-N bond formation, remain scarce. In this study, we present the design and synthesis of a series of characterizable palladium(IV) amido alkyl complexes. These high-valent complexes exhibit different reactivities and selectivities in C(sp3)-N and C(sp3)-C(carbene) couplings. Through the characterization of Pd(IV) species, controlled experiments, and DFT calculations, this study provides a detailed analysis of C(sp3)-N bond formation from a Pd(IV) amido-alkyl system.
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