Related Experiment Video
Updated: May 6, 2026
04:04
Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
698
Esthetic Unit-Based Surgical Management of Large Facial Plexiform Neurofibromas
Tuan-Anh Hoang1,2, Diep L Le3, Thang D Nguyen1
1Department of Plastic Surgery, Hanoi Medical University.
The Journal of Craniofacial Surgery
|May 5, 2026
Summary
A staged surgical approach for large facial plexiform neurofibromas in neurofibromatosis type 1 (NF1) patients significantly improves facial symmetry and patient satisfaction. This method combines staged resection with tailored reconstruction for reliable functional and aesthetic recovery.
Area of Science:
- Plastic Surgery
- Oncology
- Genetics
Background:
- Large facial plexiform neurofibromas in neurofibromatosis type 1 (NF1) cause significant disfigurement and functional issues.
- Complete tumor excision is often impossible due to infiltrative growth and high vascularity.
Purpose of the Study:
- To evaluate the outcomes of an aesthetic unit-based, staged surgical approach for managing large facial plexiform neurofibromas in NF1 patients.
Main Methods:
- Retrospective review of 19 NF1 patients treated between 2018 and 2024.
- Utilized an aesthetic unit-based, staged resection strategy with individualized flap reconstruction.
- Assessed outcomes using objective facial symmetry measurements and patient-reported satisfaction scales.
Main Results:
- Near-total or subtotal excision was achieved in 16 out of 19 patients, with a mean of 4 procedures per patient.
- All 19 reconstructions using local, regional, or free flaps were successful.
- Significant improvement in facial symmetry (mean Facial Symmetry Index decreased from 1.35 to 1.12) and high patient satisfaction (mean Global Aesthetic Improvement Scale score of 4.2/5) were observed.
Conclusions:
- An aesthetic unit-based, staged excision and reconstruction approach provides reliable functional recovery and excellent aesthetic results for large facial plexiform neurofibromas in NF1 patients.
