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An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients

Tina Marinelli1,2, Shahid Husain3,4

  • 1Department of Infectious Diseases and Microbiology, Royal Prince Alfred Hospital, Sydney, Australia.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|May 5, 2026
PubMed

Insights

Invasive fungal infections (IFIs) are a persistent threat for solid organ transplant recipients (SOTRs). This review updates IFI epidemiology and prevention strategies, emphasizing the need for further research to reduce patient mortality.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Transplantation

Background:

  • Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in solid organ transplant recipients (SOTRs).
  • The incidence of IFIs in SOTRs has remained unchanged despite advances in antifungal therapies.
  • Recent data on IFI epidemiology and prevention in SOTRs are crucial for clinical practice.

Purpose of the Study:

  • To provide an updated narrative review on the epidemiology and prevention of IFIs in SOTRs.
  • To focus on studies and data published after 2019.
  • To highlight emerging challenges and encourage future research.

Main Methods:

  • Narrative review of scientific literature.
  • Focus on studies published after 2019.
  • Synthesis of epidemiological data and prevention strategies.

Main Results:

  • IFI incidence in SOTRs remains a significant challenge.
  • Updated epidemiological trends and risk factors for IFIs in SOTRs.
  • Current prevention strategies and their limitations.

Conclusions:

  • IFI remains a critical complication in SOTRs, necessitating ongoing vigilance.
  • Further research into IFI epidemiology and prevention is essential.
  • Improved strategies are needed to reduce IFI-related morbidity and mortality in SOTRs.

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