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Updated: May 6, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Unified Photoredox Platform for Divergent SO2-Capture Transformations: Substrate-Controlled Switch toward
Abhaykumar Vishwakarma1, Rahimuddin Khan1, Adithya K P2
1Organic Synthesis Laboratory, Department of Chemistry, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Argul 752050, Odisha, India.
None:
A visible-light photoredox blueprint enabling substrate-controlled SO2 incorporation and divergence in acrylamide derivatives is delineated. α-Substituted N-anisyl acrylamides undergo a rare 1,4-HAT-driven 1,2-hydrosulfonylation, whereas other tested N-benzyl analogues selectively furnish sulfonylative spiro-γ-lactams. The method tolerates diverse radical precursors, offers a broad scope, and is supported by mechanistic studies including radical trapping, isotope labeling, and DFT analysis. Selected products show notable antibacterial and antifungal activity, highlighting the therapeutic potential of the resulting S(VI) scaffolds.
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