Related Experiment Video
Updated: May 6, 2026
07:34
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
Published on: May 5, 2018
11.1K
Maternal Cardiac Disease and Congenital Heart Disease Risk in Offspring.
Yanji Qu1,2, Xiaoqing Liu1,2, Shao Lin3
1Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
JAMA Network Open
|May 5, 2026
Summary
Maternal adult congenital heart disease (ACHD) and acquired heart disease (AHD) increase offspring congenital heart disease (CHD) risk. Identifying and modifying maternal factors can help reduce these risks in high-risk pregnancies.
Area of Science:
- Cardiology
- Maternal-Fetal Medicine
- Genetics
Background:
- Maternal adult congenital heart disease (ACHD) is linked to increased offspring congenital heart disease (CHD) risk, but data from resource-limited settings are scarce.
- The association between maternal acquired heart disease (AHD) and offspring CHD remains largely unknown.
Purpose of the Study:
- To quantify CHD risk in offspring linked to maternal ACHD and AHD.
- To examine adverse outcomes in offspring with CHD born to mothers with ACHD or AHD.
- To identify maternal factors influencing the association between maternal cardiac diseases and offspring CHD risk.
Main Methods:
- Prospective birth cohort study in China (2011-2021).
- Included pregnant women with ACHD, AHD, or no cardiac disease.
- Offspring CHD diagnosed via echocardiography; log-binomial regression used for risk assessment.
Main Results:
- Maternal ACHD and AHD were associated with significantly higher offspring CHD risk (RR 1.71 and 1.38, respectively).
- Minor CHDs, particularly septal defects, showed the strongest association with maternal ACHD and AHD.
- Maternal cardiac disease was linked to increased rates of preterm birth, chromosomal, and genetic aberrations in offspring with CHD.
Conclusions:
- Maternal ACHD and AHD are associated with increased risks and adverse outcomes for offspring CHD.
- Targeting identified maternal factors may mitigate offspring CHD risk in high-risk pregnancies.
Related Concept Videos
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
810
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
810
01:25Cardiomyopathy I: Introduction and Classification
828
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
828
01:26Imbalances in Cardiac Output
3.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
01:19Mitral Valve Prolapse III: Nursing Management
588
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
588
01:30Cardiomyopathy II: Dilated Cardiomyopathy
798
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
798
01:22Mitral Stenosis I: Introduction
1.8K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.8K