Related Experiment Video

Updated: May 6, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

1.8K

Tigecycline use in children with multidrug-resistant infections: a single-center experience

Mustafa Gençeli1, Talha Üstüntaş2, Özge Metin Akcan2

  • 1Department of Pediatric Infectious Disease, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Expert Review of Anti-Infective Therapy
|May 5, 2026
PubMed

Insights

Tigecycline showed good outcomes and tolerability in critically ill children with multidrug-resistant gram-negative infections. Further trials are needed to confirm these findings in pediatric populations.

Area of Science:

  • Pediatric infectious diseases
  • Antimicrobial stewardship
  • Critical care medicine

Background:

  • Limited pediatric data exists for tigecycline in treating multidrug-resistant gram-negative bacterial infections.
  • This study evaluates tigecycline's effectiveness and safety in critically ill children.

Purpose of the Study:

  • To assess clinical outcomes and tolerability of tigecycline in pediatric patients with multidrug-resistant infections.
  • To identify predictors of treatment success and mortality.

Main Methods:

  • Retrospective cohort study of 143 pediatric patients treated with tigecycline.
  • Analysis included clinical success rates, infection-related mortality, and laboratory assessments for tolerability.
  • Logistic regression and Cox modeling were used to identify predictors.

Main Results:

  • Clinical success was achieved in 76.9% of patients, with *Klebsiella pneumoniae* and *Acinetobacter baumannii* being the most common pathogens.
  • Intensive care admission and combination therapy were associated with treatment failure.
  • Infection-related mortality was 28.7%, with intensive care admission as the only independent predictor; no significant organ toxicity was observed.

Conclusions:

  • Tigecycline demonstrated favorable outcomes and acceptable tolerability in critically ill children with multidrug-resistant infections.
  • Limitations include the retrospective design and lack of a control group.
  • Prospective trials are recommended to validate these findings.
Abstract

Keywords:
Carbapenem resistanceglycylcyclinemultidrug-resistant infectionspediatric infectious diseasesretrospective cohort studytigecycline

More Related Videos

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K
A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers10:49

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers

Published on: September 26, 2019

5.2K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
413
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
975
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
106
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
558
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
1.0K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K