Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

14.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.6K
T Cell Types and Functions01:24

T Cell Types and Functions

3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The chordoid glioma <i>PRKCA</i> D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice.

Science signaling·2025
Same author

WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth.

Nature communications·2025
Same author

WNK1-dependent water influx is required for CD4<sup>+</sup> T cell activation and T cell-dependent antibody responses.

Nature communications·2025
Same author

Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2024
Same author

Loss of ARID3A perturbs intestinal epithelial proliferation-differentiation ratio and regeneration.

The Journal of experimental medicine·2024
Same author

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.

Science translational medicine·2024
Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026
Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026
Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026
Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026
Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026
Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026
See all related articles

Related Experiment Video

Updated: May 7, 2026

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

4.6K

TACI regulates marginal zone B cell development.

Daisy H Luff1, Lesley Vanes1, Stefan Boeing1

  • 1The Francis Crick Institute , London, UK.

The Journal of Experimental Medicine
|May 5, 2026
PubMed
Summary
This summary is machine-generated.

Tumor necrosis factor receptor superfamily member TACI plays a key role in marginal zone (MZ) B cell development. Loss of TACI impairs T-independent antibody responses by affecting MZ B cell numbers.

More Related Videos

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

25.3K
Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.0K

Related Experiment Videos

Last Updated: May 7, 2026

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

4.6K
A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

25.3K
Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
06:15

Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay

Published on: September 7, 2018

9.0K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Mature B cell populations include follicular and marginal zone (MZ) B cells, originating from transitional type 2 (T2) B cells.
  • TACI (TNF receptor superfamily member) is expressed on mature B cells, particularly MZ B cells and plasma cells.
  • Prior research suggested TACI negatively regulates B cell survival, but this was confounded by BAFF levels in TACI-deficient mice.

Purpose of the Study:

  • To investigate the precise role of TACI in B cell development and survival.
  • To clarify the function of TACI in marginal zone (MZ) B cell development.
  • To elucidate the molecular mechanisms by which TACI influences B cell populations.

Main Methods:

  • Analysis of B cell populations in TACI-deficient mice.
  • Assessment of T-independent antibody responses.
  • Investigation of signaling pathways (PI3K-AKT, FOXO1) involved in TACI function.

Main Results:

  • TACI does not directly regulate B cell survival but is crucial for MZ B cell development.
  • TACI deficiency results in decreased MZ B cell numbers.
  • Impaired T-independent antibody responses were observed in TACI-deficient mice.

Conclusions:

  • TACI has a cell-intrinsic role in the development of MZ B cells from T2 precursors.
  • TACI signaling, via PI3K-AKT and FOXO1, is essential for proper MZ B cell maturation.
  • These findings correct previous understandings of TACI's function in B cell biology.