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Health coach-supported mobile health intervention to improve adherence to lipid-lowering medications (AdLip): Design

Qi Chwen Ong1, Emina Obarcanin1, Iva Bojic1

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Plos One
|May 5, 2026
PubMed

Insights

This study evaluates a mobile health app with human coaching to improve statin adherence in adults with high cholesterol. The AdLip trial aims to enhance cardiovascular disease prevention through personalized interventions.

Area of Science:

  • Cardiology
  • Digital Health
  • Public Health

Background:

  • Elevated low-density lipoprotein cholesterol (LDL-C) is a key modifiable risk factor for cardiovascular disease (CVD).
  • Suboptimal adherence to lipid-lowering medications, particularly statins, hinders effective lipid management and CVD prevention.
  • Personalized, multicomponent interventions are needed to address medication non-adherence.

Purpose of the Study:

  • To evaluate the effectiveness of a human coach-supported digital personal health assistant (mobile health app) intervention.
  • To improve adherence to statins in adults diagnosed with hyperlipidaemia.
  • To assess the impact on cardiovascular disease risk factors and patient-reported outcomes.

Main Methods:

  • A multicentre, open-label, randomized controlled trial (AdLip) involving at least 376 non-adherent adult statin users.
  • Participants randomly assigned to either a mobile health app intervention with human coaching or a control group.
  • Primary outcome: statin adherence at 6 months (Medication Adherence Report Scale-5); secondary outcomes include LDL-C levels, motivation, self-efficacy, and quality of life.

Main Results:

  • This section is not available in the provided abstract.
  • Further analysis will be conducted using an intention-to-treat approach.

Conclusions:

  • The AdLip trial will offer evidence on a multicomponent strategy for statin non-adherence in a multi-ethnic Asian population.
  • Findings may guide personalized interventions for non-adherence and long-term CVD prevention.
  • Trial registration: ClinicalTrials.gov NCT06614049.
Abstract

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