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Early decrease in circulating miR-21 correlates with preeclampsia occurrence and Outcomes: A retrospective study.

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Pregnancy Hypertension
|May 5, 2026
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Summary

Reduced first-trimester miR-21 levels indicate a higher risk of preeclampsia (PE), its severity, and adverse outcomes. Early measurement of miR-21 shows potential as a biomarker for predicting PE and guiding patient management.

Keywords:
BiomarkerOutcomesPregnantRiskmicroRNAs

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Area of Science:

  • Biochemistry
  • Genetics
  • Obstetrics

Background:

  • Preeclampsia (PE) poses significant risks to maternal and neonatal health.
  • Current screening methods for PE lack sufficient predictive accuracy.
  • Circulating microRNAs, particularly miR-21, are emerging as potential biomarkers for PE.

Purpose of the Study:

  • To investigate the association between first-trimester miR-21 levels and the development, severity, and outcomes of preeclampsia.
  • To evaluate the predictive value of miR-21 for PE risk and prognosis.

Main Methods:

  • Retrospective analysis of plasma samples from 148 women with PE and 95 controls.
  • qRT-PCR used to quantify miR-21 expression at 11-13 weeks gestation and at PE diagnosis.
  • Correlation analysis with clinical data including blood pressure, proteinuria, and perinatal outcomes.

Main Results:

  • First-trimester miR-21 levels were significantly lower in women who developed PE (p < 0.001).
  • Lower miR-21 levels correlated with increased PE severity, higher blood pressure, and greater proteinuria.
  • First-trimester miR-21 levels demonstrated prognostic value for poor pregnancy outcomes (AUC = 0.77).

Conclusions:

  • Reduced circulating miR-21 in early pregnancy is linked to increased PE risk, severity, and adverse outcomes.
  • Early miR-21 measurement may serve as a valuable biomarker for PE risk prediction and personalized management.