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Nuclear Factor-Y Controls Neurite Extension by Balancing BMP Signaling.

Pedro Moreira1, Paul Papatheodorou2, Roger Pocock1

  • 1Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia pedro.moreira@monash.edu roger.pocock@monash.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 5, 2026
PubMed
Summary
This summary is machine-generated.

The Nuclear Factor-Y (NF-Y) transcription factor regulates neuron development and axon guidance. NF-Y acts with other pathways, like Bone Morphogenetic Protein (BMP) signaling, to ensure correct nervous system wiring.

Keywords:
BMP signalingCaenorhabditis elegansneurite developmenttranscription factor

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Neuronal circuit formation relies on guidance molecules, but transcriptional regulation is unclear.
  • Nuclear Factor-Y (NF-Y) is a conserved transcription factor complex.
  • NF-Y subunits (NF-YA, NF-YB, NF-YC) regulate gene expression.

Purpose of the Study:

  • Identify transcriptional regulators of neuronal circuit formation.
  • Investigate the role of NF-Y in neuron fate and axon guidance.
  • Elucidate NF-Y's function in neurite development.

Main Methods:

  • Conducted an unbiased genetic screen in *Caenorhabditis elegans*.
  • Utilized serotonergic neurosecretory-motor neurons (NSM) as a model system.
  • Examined the effects of NFYA-1 loss and BMP signaling manipulation.

Main Results:

  • NF-Y, specifically NFYA-1, controls neurite development in multiple neuronal subtypes.
  • NFYA-1 acts cell-autonomously to limit dorsal neurite length in NSM neurons.
  • Loss of NFYA-1 leads to neurite overextension, which is suppressed by DBL-1/BMP signaling.

Conclusions:

  • NF-Y is a key transcriptional regulator of neurodevelopmental events.
  • NF-Y functions in parallel with established neuronal guidance mechanisms.
  • A significant connection exists between NF-Y and BMP signaling in controlling neurite extension across species.