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Related Experiment Video

Updated: May 7, 2026

Methods for Detecting Cough and Airway Inflammation in Mice

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Occupational, Environmental, and Irritant-induced Cough.

Benjamin Wajsberg¹, Michael S Benninger²

¹Cleveland Clinic Voice Center, Head and Neck Institute, Cleveland Clinic, Cleveland, OH, USA.

Otolaryngologic Clinics of North America

|May 5, 2026

Summary

This summary is machine-generated.

Occupational exposures to airway irritants are a common cause of chronic cough. Recognizing these triggers requires detailed histories and workplace protections to manage persistent respiratory symptoms.

Keywords:

Airway hypersensitivity Environmental irritants Neurogenic inflammation Occupational cough TRPV1

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Area of Science:

Environmental Health
Occupational Medicine
Pulmonology

Background:

Chronic cough is frequently linked to occupational and environmental exposures, though often overlooked.
Airway irritants activate sensory neurons via transient receptor potential ion channels, leading to sensitization.
Industrial exposures like isocyanates, dusts, fumes, and pollutants are common triggers.

Purpose of the Study:

To highlight the underrecognized role of occupational and environmental exposures in chronic cough.
To emphasize the mechanism of airway irritant-induced cough sensitization.
To advocate for systematic exposure assessment in clinical practice.

Main Methods:

Review of literature on occupational exposures and chronic cough.
Explanation of the neurobiological mechanisms of airway sensitization.
Analysis of clinical practice gaps in exposure assessment.

Main Results:

Occupational and environmental factors are significant contributors to chronic cough.
Exposure to irritants causes persistent peripheral and central sensitization of airway neurons.
Systematic exposure evaluation is not routinely performed in clinical settings.

Conclusions:

Accurate diagnosis of occupationally related chronic cough requires thorough exposure histories.
Temporal correlation between exposure and symptom onset is crucial for identification.
Multidisciplinary collaboration is essential for effective workplace interventions and protections.