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Methods for Detecting Cough and Airway Inflammation in Mice
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Upper Airway Cough Syndrome.

Nasser Lubega1, Kareem Al-Mulki1, Janalee Stokken1

  • 1Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA.

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Summary

Upper airway cough syndrome (UACS), previously postnasal drip syndrome, is a common cause of chronic cough. Management focuses on controlling inflammation and mucus production to resolve cough.

Keywords:
Chronic coughCough reflex hypersensitivityInflammationPostnasal dripRhinitisRhinosinusitisUpper airway cough syndrome

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Area of Science:

  • Otolaryngology
  • Pulmonology
  • Allergy and Immunology

Background:

  • Upper airway cough syndrome (UACS), formerly postnasal drip syndrome, is a frequent cause of chronic cough.
  • UACS involves upper airway disorders like allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis.
  • These conditions trigger cough via mucosal inflammation and hypersensitivity.

Purpose of the Study:

  • To review the pathophysiology, diagnosis, and management of UACS.
  • To provide an otolaryngologic perspective on UACS.
  • To discuss evidence-based treatment strategies for UACS.

Main Methods:

  • Literature review of UACS pathophysiology, diagnosis, and management.
  • Focus on an otolaryngologic viewpoint.
  • Analysis of evidence-based treatment approaches.

Main Results:

  • UACS is a common cause of chronic cough, linked to upper airway inflammation.
  • Clinical differentiation is key due to the absence of a definitive diagnostic test.
  • Treatment targets airway inflammation and mucus production.

Conclusions:

  • UACS management requires addressing underlying upper airway inflammation and hypersensitivity.
  • Targeted therapies can effectively resolve chronic cough associated with UACS.
  • An otolaryngologic approach is crucial for comprehensive UACS care.