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DUSP family phosphatases in cell signaling, inflammation, and chronic diseases

Chia-Wen Wang1, Huai-Chia Chuang1, Tse-Hua Tan2

  • 1Immunology Research Center, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Taiwan.

Journal of Biomedical Science
|May 5, 2026
PubMed

Insights

Dual-specificity phosphatases (DUSPs) regulate mitogen-activated protein kinases (MAPKs). Dysregulated DUSPs are implicated in inflammatory diseases, offering potential diagnostic and therapeutic targets.

Area of Science:

  • Biochemistry and Molecular Biology
  • Immunology
  • Pathology

Background:

  • Dual-specificity phosphatases (DUSPs) are critical regulators of mitogen-activated protein kinases (MAPKs).
  • Dysregulation of DUSPs is linked to the pathogenesis of numerous human inflammatory and chronic diseases, including autoimmune, allergic, inflammatory bowel, metabolic, and cardiovascular diseases.
  • Specific DUSP members show altered expression patterns (downregulation or upregulation) across different disease states.

Purpose of the Study:

  • To review the roles and regulatory mechanisms of DUSPs in human inflammatory and chronic diseases.
  • To explore the potential therapeutic applications of DUSP modulators (agonists/inhibitors).

Main Methods:

  • Literature review summarizing existing research on DUSP involvement in various diseases.
  • Analysis of DUSP expression patterns and their association with disease pathogenesis.
  • Discussion of DUSP regulatory mechanisms and therapeutic potential.

Main Results:

  • DUSP dysregulation is a common feature across diverse inflammatory and chronic diseases.
  • Specific DUSPs are implicated in autoimmune diseases (e.g., DUSP1, DUSP4), allergic diseases (e.g., DUSP1, DUSP8), inflammatory bowel diseases (e.g., DUSP2, DUSP11), metabolic diseases, and cardiovascular diseases.
  • Altered DUSP expression can serve as diagnostic biomarkers and therapeutic targets.

Conclusions:

  • Dysregulated DUSPs are key players in the pathogenesis of inflammatory and chronic diseases.
  • Understanding individual DUSP regulatory mechanisms is crucial for developing targeted therapies.
  • DUSP agonists and inhibitors represent promising therapeutic strategies for managing these conditions.
Keywords:
Allergic diseasesAutoimmune diseasesCardiovascular diseasesDUSPDiabetesInflammationMKPMetabolic diseasesObesityPhosphatase

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