Related Experiment Video
Updated: May 7, 2026
Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft
Published on: June 6, 2025
Perioperative Bisphosphonate Therapy Reduces the Rate of Retear After Rotator Cuff Repair: A Systematic Review and
Napatpong Thamrongskulsiri1,2,3, Thun Itthipanichpong1,2, Danaithep Limskul1,2
1Sports Medicine Research Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
None:
This study evaluated the effect of bisphosphonate therapy on tendon healing and clinical outcomes after arthroscopic rotator cuff repair in patients with osteoporosis. PubMed, Scopus, and Ovid MEDLINE were searched from inception to January 2026 to identify comparative studies of osteoporotic patients treated with bisphosphonates versus no bisphosphonate therapy. Five studies met the inclusion criteria. Bisphosphonate therapy was associated with a significantly lower rate of structural tendon retear (odds ratio, 0.32; 95% confidence interval, 0.18-0.59; P =0.0002). No significant differences were observed between groups in postoperative American Shoulder and Elbow Surgeons scores, Constant scores, or reoperation rates. Patients receiving bisphosphonates demonstrated a modest but statistically significant improvement in postoperative forward flexion (mean difference, 8.28°; 95% confidence interval, 3.54-13.02). No serious bisphosphonate-related adverse events were reported.
