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Related Experiment Video

Updated: May 7, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
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Enhancement of Skin Barrier Function Using DYNAMiQ Technology: A Clinical Evaluation.

Klaus Fritz1, Mariya Genova2, Carmen Salavastru3,4

  • 1Dermatology and Laser Center, Landau in der Pfalz, Germany.

Journal of Cosmetic Dermatology
|May 6, 2026
PubMed
Summary

DYNAMiQ technology significantly improves skin barrier function by reducing transepidermal water loss (TEWL). This restorative effect leads to enhanced skin hydration and subject satisfaction.

Keywords:
TEWLcalcium gradienthydrationskin barrierskin health

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Area of Science:

  • Dermatology
  • Cosmetic Science
  • Skin Health

Background:

  • The skin barrier is crucial for defense against environmental factors.
  • Barrier disruption is linked to skin issues like inflammation and aging.
  • Technologies that reinforce the skin barrier are vital for skin health.

Purpose of the Study:

  • To assess the restorative impact of DYNAMiQ technology on skin barrier function.
  • Evaluate DYNAMiQ's ability to enhance skin barrier integrity.

Main Methods:

  • Prospective study with 24 female participants (26-64 years).
  • DYNAMiQ treatment administered once, with follow-up at 7 days.
  • Measured transepidermal water loss (TEWL) pre-treatment, post-treatment, and at follow-up.

Main Results:

  • TEWL decreased by 80.3% by day 7 post-treatment (6.63 ± 0.18 g/m²/h).
  • Immediate post-treatment TEWL showed a slight increase.
  • 100% of subjects reported satisfaction; 96% noted improved skin hydration.

Conclusions:

  • DYNAMiQ technology effectively restores skin barrier function.
  • Significant reduction in TEWL confirms improved barrier integrity.
  • High subject satisfaction and perceived hydration validate the technology's efficacy.