Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

58.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
58.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

1,12-cyclic-apelin-12 counters vascular smooth muscle cell proliferation and atherosclerosis through inhibiting aerobic glycolysis.

Toxicology and applied pharmacology·2026
Same author

Viral pathogen infection drives deterministic assembly of plant endophytic microbiomes: soil properties as divergent drivers and low-abundance taxa as primary responders.

Frontiers in microbiology·2026
Same author

Emerging roles of platelet DNA in cancer detection and noninvasive prenatal testing.

Molecular pharmacology·2026
Same author

Mechanisms Associated with PINK1 Variants in Parkinson's Disease.

F1000Research·2026
Same author

Neohesperidin Regulates Lipid Metabolism and Ameliorates MASLD by Targeting ECHS1.

Phytotherapy research : PTR·2026
Same author

Subinhibitory Concentrations of Rifampicin Synergize with Linezolid to Delay Resistance Evolution in Clinical Methicillin-Resistant Staphylococcus Aureus.

Microorganisms·2026

Related Experiment Video

Updated: May 7, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:07

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

1.7K

Association between circulating metabolites and endometriosis: a bidirectional two-sample Mendelian randomization

Lele Pan1,2, Yuying Chen2, Yuzhen Cao2

  • 1Department of Obstetrics and Gynecology, Guangdong Women and Children Hospital, Guangzhou, China.

Obstetrics & Gynecology Science
|May 6, 2026
PubMed
Summary

Genetically elevated diacylglycerol levels are linked to increased endometriosis risk. This study identifies key metabolite associations, improving understanding of the condition's metabolic profile.

Keywords:
EndometriosisGenome-wide association studyMendelian randomizationPlasma metabolites

More Related Videos

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.1K

Related Experiment Videos

Last Updated: May 7, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:07

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

1.7K
A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

5.1K

Area of Science:

  • Gynecology
  • Metabolomics
  • Genetic Epidemiology

Background:

  • Endometriosis (EM) is a chronic gynecological condition with unknown causes.
  • Metabolite levels may influence EM risk.
  • Understanding metabolic associations can offer new insights into EM etiology.

Purpose of the Study:

  • To investigate the association between 233 metabolites and endometriosis risk using a two-sample Mendelian randomization (MR) approach.
  • To explore potential causal relationships between specific metabolites and EM.
  • To identify metabolic biomarkers associated with endometriosis.

Main Methods:

  • A bidirectional two-sample Mendelian randomization (MR) analysis was performed using publicly available genetic data.
  • Associations between 233 metabolites and EM were assessed.
  • Sensitivity analyses were conducted to ensure the robustness of the findings, including tests for pleiotropy, with Bonferroni correction applied.

Main Results:

  • Genetically elevated diacylglycerol levels showed a significant association with increased EM risk (OR, 1.225; P=1.16×10-7), representing a 22.5% risk increase per standard deviation.
  • Several other metabolites, including ratios of 3-hydroxybutyrate and saturated fatty acids, and total cholesterol to total lipids in very low-density lipoproteins, were nominally associated with higher EM risk.
  • Reverse MR analysis indicated nominal associations between increased conjugated linoleic acid (CLA) and tyrosine levels, and the CLA to total fatty acid ratio, with EM.

Conclusions:

  • This study provides robust evidence linking specific metabolites, particularly diacylglycerol, to endometriosis risk.
  • The findings enhance the understanding of the metabolic profile associated with endometriosis.
  • Further research into these metabolic pathways may reveal novel therapeutic targets for EM.