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Updated: May 7, 2026

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4D-Printed Sandwich-Structured Metamaterial Intestinal Stents for Palliative Tumor Therapy.

Cheng Lin1, Mengjiao Yang1, Kang Chen2

  • 1Centre For Composite Materials and Structures, Harbin Institute of Technology, Harbin, China.

Advanced Materials (Deerfield Beach, Fla.)
|May 6, 2026
PubMed
Summary

This study introduces a 4D-printed intestinal stent for colorectal cancer patients, offering sustained anti-tumor effects and customized configuration to relieve obstruction and prevent restenosis.

Keywords:
4D printinganti‐tumorintestinal obstructionintestinal stentmetamaterial

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Colorectal cancer frequently causes intestinal obstruction, requiring palliative stenting for non-surgical candidates.
  • Current intestinal stents lack sustained anti-tumor efficacy and can deform, leading to restenosis and treatment challenges.

Purpose of the Study:

  • To develop a novel 4D-printed, multi-layered intestinal stent platform for colorectal cancer management.
  • To achieve sustained anti-tumor effects, customized configuration, and rapid relief of intestinal obstruction.

Main Methods:

  • Fabrication of a 4D-printed, sandwich-structured metamaterial intestinal stent.
  • Incorporation of a Janus outer layer for combined photothermal and drug therapy.
  • Design of an intermediate biomimetic gradient metamaterial layer for structural support.
  • Inclusion of a hydrophobic inner layer to prevent restenosis.

Main Results:

  • The developed stent platform demonstrated sustained anti-tumor effects.
  • Customized configuration and coordinated deformation were achieved.
  • Rapid relief of intestinal obstruction was observed.
  • The stent design effectively mitigated the risk of restenosis.

Conclusions:

  • A multifunctional intestinal stent platform was successfully developed using a scalable design.
  • This innovative stent offers a clinically translatable therapeutic strategy for personalized colorectal cancer management.
  • The stent addresses limitations of current treatments by providing sustained anti-tumor efficacy and improved structural integrity.