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Optimizing adhesive protocols for CAD-CAM restorations: Is simplification a reliable alternative to conventional
1Department of Restorative Dentistry, Faculty of Dentistry, Istanbul University-Cerrahpasa, Istanbul, Turkey.
The Journal of Advanced Prosthodontics
|May 6, 2026
Summary
The conventional three-step silane protocol offers the most durable bond for CAD-CAM materials. Simplified strategies provide acceptable alternatives, though bond strength varies by material type and aging.
Area of Science:
- Dental Materials Science
- Biomaterials Engineering
- Restorative Dentistry
Background:
- Computer-Aided Design/Computer-Aided Manufacturing (CAD-CAM) restorations require durable bonding to tooth structure.
- Optimizing silane-based surface treatments is crucial for enhancing the bond strength of various CAD-CAM materials.
- Understanding the impact of aging on bond durability is essential for clinical longevity.
Purpose of the Study:
- To compare the bond strength and surface morphology of five CAD-CAM materials.
- To evaluate the efficacy of different silane-based bonding strategies.
- To assess the influence of artificial aging on bond durability.
Main Methods:
- Five CAD-CAM materials (leucite-reinforced glass ceramic, lithium disilicate, zirconia-reinforced lithium silicate, polymer-infiltrated ceramic network, resin nanoceramic) were tested.
- Specimens were subjected to five bonding protocols: conventional silane, universal adhesive, single-step cement, ceramic primer, and no silane.
- Bond strength was measured via micro-shear testing before and after 10,000 thermal cycles; failure modes and surface morphology were analyzed.
Main Results:
- Material type, bonding strategy, and aging significantly impacted bond strength (P < .001).
- The conventional silane protocol yielded the highest bond strength across all materials.
- Simplified strategies showed intermediate, clinically acceptable bond strengths, though reduced by thermal cycling.
Conclusions:
- The conventional three-step silane protocol ensures the most reliable and durable bonding for CAD-CAM restorations.
- Simplified bonding strategies can be acceptable alternatives, contingent upon the specific CAD-CAM material used.
- Artificial aging consistently reduced bond strength, highlighting the importance of robust bonding protocols.

