Evaluation of left intraventricular flow dynamics using the novel non-contrast HyperDoppler technique
Riccardo Beccari1, Antonella Cecchetto1, Vittorio Smarrazzo2
1Cardiac Unit, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
Summary
HyperDoppler ultrasound provides reproducible reference values for left ventricular (LV) flow dynamics. This technique quantifies intracardiac flow, aiding clinical assessment of LV function.
Area of Science:
- Cardiovascular Ultrasound
- Hemodynamics
- Echocardiography
Background:
- The HyperDoppler technique, a color Doppler ultrasound method, has emerged for evaluating left ventricular (LV) flow dynamics.
- Quantitative data from HyperDoppler in clinical settings remain limited.
- Establishing reference values and assessing reproducibility are crucial for its clinical adoption.
Purpose of the Study:
- To establish reference values for key HyperDoppler measures of LV flow dynamics in normal subjects.
- To determine the reproducibility of HyperDoppler measures: vortex area, length, depth, intensity, and global kinetic energy dissipation (gKED).
- To investigate the influence of physiological and echocardiographic variables on these measures.
Main Methods:
- A multicenter, international study involving 13 echocardiographic laboratories and an independent core laboratory.
- Analysis of 467 normal subjects categorized by age and gender.
- Quantitative analysis of HyperDoppler cineloops using standardized protocols.
Main Results:
- Median reference values were established: vortex area (25.0%), length (57.4%), depth (34.3%), intensity (-31.9%), and gKED (0.55).
- Minor age- and gender-related variations observed in vortex length, depth, and gKED.
- Excellent reproducibility demonstrated for all HyperDoppler measures, confirming reliable assessment of LV flow dynamics.
Conclusions:
- Reference values for left intraventricular flow dynamics using HyperDoppler have been successfully established.
- The HyperDoppler technique is reproducible and suitable for assessing intracardiac flow dynamics in clinical practice.
- This study provides a foundation for utilizing HyperDoppler in routine clinical evaluations of LV function.
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