Related Experiment Video
Updated: May 7, 2026

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
Changes in the Epidemiology of Pediatric Olfactory Dysfunction Before and After COVID-19 Pandemic
Yuji Kishimoto1, Eri Mori1, Rinko Sakurai1
1Department of Otorhinolaryngology Head and Neck Surgery The Jikei University School of Medicine Tokyo Japan.
Insights
The COVID-19 pandemic increased pediatric olfactory dysfunction, with upper respiratory infections, especially COVID-19, becoming the leading cause. Parosmia emerged as a key symptom in children post-COVID-19.
Area of Science:
- Otolaryngology
- Pediatric Health
- Infectious Disease Epidemiology
Background:
- Limited data exist on pediatric olfactory dysfunction changes post-COVID-19.
- Investigating etiological shifts and qualitative symptoms like parosmia in children is crucial.
Purpose of the Study:
- To investigate temporal changes in pediatric olfactory dysfunction presentations.
- To analyze etiological factors and symptom profiles before and after the COVID-19 pandemic.
Main Methods:
- Retrospective review of pediatric patients (<18 years) with olfactory dysfunction (Jan 2009-Dec 2024).
- Division into pre-pandemic (Jan 2009-Mar 2020) and post-pandemic (Apr 2020-Dec 2024) cohorts.
- Etiology determination via clinical history, imaging, endoscopy, and olfactory testing.
Main Results:
- Proportion of pediatric patients increased significantly post-pandemic (1.5% to 4.7%).
- Upper respiratory tract infection, largely COVID-19 related, became the leading cause, replacing olfactory cleft stenosis.
- Parosmia was exclusively observed in post-COVID-19 pediatric patients; subjective scores indicated milder perceived dysfunction.
Conclusions:
- Pediatric olfactory dysfunction is more frequent post-COVID-19, primarily due to post-infectious causes like COVID-19.
- Parosmia is a characteristic feature of pediatric olfactory dysfunction following COVID-19.
- Increased clinical awareness and pediatric-specific diagnostic standards are necessary.
Background:
The COVID-19 pandemic may have altered the epidemiology and clinical features of pediatric olfactory dysfunction, but data focusing on children remain limited, particularly regarding etiological changes and qualitative symptoms such as parosmia. This study investigated temporal changes in pediatric presentations at a tertiary smell clinic.
Methodology/Principal:
We retrospectively reviewed patients younger than 18 years who visited our clinic for olfactory dysfunction between January 2009 and December 2024. Patients were divided into pre-pandemic (January 2009-March 2020) and post-pandemic (April 2020-December 2024) cohorts. Etiology was determined using clinical history, imaging, nasal endoscopy, and psychophysical and subjective olfactory tests.
Results:
The proportion of pediatric patients among all patients with olfactory dysfunction increased significantly from 1.5% (35/2322) in the pre-pandemic cohort to 4.7% (48/1022) in the post-pandemic cohort (p < 0.01), with a corresponding decrease in adults. Etiological distribution shifted significantly (p < 0.01): olfactory cleft stenosis predominated in pre-pandemic, whereas upper respiratory tract infection became the leading cause in the post-pandemic cohort, 76% of cases of which related to COVID-19. Parosmia was observed exclusively in post-COVID-19 pediatric patients. Subjective olfactory scores were higher with post-pandemic patients, indicating more mildly perceived dysfunction, while psychophysical test results showed no significant differences.
Conclusions:
After the COVID-19 pandemic, pediatric olfactory dysfunction became more frequent and was predominantly associated with post-infectious causes, particularly COVID-19, with parosmia emerging as a characteristic feature. Greater clinical awareness and pediatric-specific diagnostic standards will be needed.
Level Of Evidence:
Level 3.
More Related Videos
Related Concept Videos
Olfactory Receptors: Location and Structure
Olfaction
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway
The olfactory...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

