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Peaked-to-flat transition in quasispecies structure evolution.

Josep Gregori1, Sergi Colomer-Castell1,2,3, Carolina Campos1,2,3

  • 1Liver Diseases-Viral Hepatitis, Liver Unit, Vall d'Hebron Institute of Research (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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Summary
This summary is machine-generated.

Viral quasispecies evolve towards a "flat-like" state, increasing genetic diversity and evenness. This viral evolution impacts treatment efficacy and disease resilience, even without resistance mutations.

Keywords:
antiviral resistancediversityevennesshaplotype synonymymaturity scorequasispecies structureviral quasispecies

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Area of Science:

  • Virology
  • Evolutionary Biology
  • Genetics

Background:

  • Hepatitis C virus (HCV) and hepatitis E virus (HEV) infections exhibit deterministic quasispecies evolution.
  • Quasispecies structure evolves towards a 'flat-like' landscape with high evenness and haplotype synonymy.

Purpose of the Study:

  • To define two idealized quasispecies states (A and Z) and describe the parabolic trajectory of evolution between them.
  • To analyze the phases of viral evolution, focusing on genetic diversity and haplotype distribution.

Main Methods:

  • Modeling the evolution of viral quasispecies structure.
  • Defining idealized quasispecies states and evolutionary trajectories.
  • Proposing a normalized quasispecies maturity score.

Main Results:

  • Viral quasispecies evolve along a parabolic trajectory from state A to state Z.
  • The initial evolutionary phase increases genetic diversity; the later phase increases haplotype evenness.
  • This progression enhances viral fitness, resilience, and treatment resistance.

Conclusions:

  • The A-to-Z evolutionary model explains challenges in treating chronic infections.
  • Viral maturity influences therapeutic failure, even without resistance mutations.
  • The quasispecies maturity score aids in understanding infection progression.