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Exercise Impacts Liver Disease: Balancing Metabolic and Immune Homeostasis
Chen Cheng1,2, Wentao Xu3,2, Shanshan Wu2,4
1School of Pharmacy, Anhui Medical University, Hefei, 230022, China.
International Journal of Biological Sciences
|May 6, 2026
Summary
Regular exercise is a powerful non-drug treatment for liver diseases like MASLD and ALD. It improves liver health and patient quality of life by targeting multiple biological pathways.
Area of Science:
- Hepatology and Exercise Science
Background:
- Liver diseases represent a substantial global health challenge.
- Non-pharmacological interventions are increasingly important for managing liver conditions.
Purpose of the Study:
- To systematically review the role of exercise in preventing and treating diverse liver diseases.
- To explore the multi-targeted mechanisms by which exercise benefits liver health.
Main Methods:
- Systematic review of existing literature on exercise and liver disease.
- Analysis of exercise's impact on conditions including MASLD, ALD, viral hepatitis, fibrosis, cirrhosis, and HCC.
Main Results:
- Exercise demonstrates efficacy in delaying disease progression across various liver conditions.
- Key benefits include improved metabolic profiles, enhanced insulin sensitivity, and modulated immune responses.
- Exercise influences hepatic stellate cell activation and the tumor microenvironment.
Conclusions:
- Exercise is a vital non-pharmacological strategy for liver disease management.
- Future research should focus on personalized exercise prescriptions and molecular mechanisms using multi-omics.
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