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Updated: May 7, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A

Michael W Brigham1, Edward S Hems2,3, Daniel C L Van1

  • 1Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds, UK.

Angewandte Chemie (International Ed. in English)
|May 6, 2026
PubMed

Keywords:
Streptomycesamino acid hydroxylaseglycopeptide antibioticsnatural product biosynthesissilent gene clusters

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