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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
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Dissociative Disorders01:27

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Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
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Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
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Related Experiment Video

Updated: May 7, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Network-level structural alterations distinguish persistent from remitted post-traumatic stress disorder: a

Suji Lee1, Hyeonji Lee1,2, Yoonji Joo2

  • 1Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea.

European Journal of Psychotraumatology
|May 6, 2026
PubMed
Summary

Persistent post-traumatic stress disorder (PTSD) shows reduced gray matter volume and increased brain network connectivity. These changes suggest compensatory mechanisms are engaged to manage ongoing symptoms in chronic PTSD.

Keywords:
Persistent post-traumatic stress disorderTrastorno por estrés postraumático persistentecompensatory hyperconnectivitycovarianza estructuralfrontal-cognitive control networkmorphometric networksred de control cognitivo frontalredes morfométricasstructural covariance

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Post-traumatic stress disorder (PTSD) has varied clinical outcomes, with some individuals experiencing chronic symptoms.
  • Neuroanatomical differences underlying persistent PTSD remain unclear.
  • Structural covariance network analysis can investigate brain organization in PTSD.

Purpose of the Study:

  • To identify structural network differences in persistent PTSD.
  • To compare brain organization in healthy controls, remitted PTSD, and persistent PTSD.
  • To elucidate neurobiological mechanisms of PTSD chronicity.

Main Methods:

  • Structural covariance network analysis using T1-weighted MRI.
  • Independent component analysis to define morphometric networks.
  • Comparison of gray matter volume and inter-network connectivity across three groups (HC, remitted PTSD, persistent PTSD).

Main Results:

  • Progressive gray matter reduction in frontal-cognitive and visual networks from HC to remitted PTSD to persistent PTSD.
  • Increased connectivity between frontal-cognitive control and temporo-insular-limbic networks in persistent PTSD compared to HC and remitted PTSD.
  • Remitted PTSD group showed connectivity similar to HC.

Conclusions:

  • Persistent PTSD is associated with gray matter volume loss and compensatory hyperconnectivity.
  • These findings suggest sustained regulatory mechanism engagement in persistent PTSD.
  • Prefrontal-limbic interactions represent potential targets for personalized interventions in treatment-resistant PTSD.