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Preference for different PrEP formulations: A cross-sectional study in a PrEP cohort in Spain
Alfredo Soler-Carracedo1, Allison R Webel2, Luis Ramos-Ruperto3
1Chelsea and Westminster Hospital, London, UK.
HIV Medicine
|May 6, 2026
Summary
Most surveyed individuals preferred long-acting pre-exposure prophylaxis (LA-PrEP) over oral formulations. They cited practicality and fewer clinic visits as key reasons for preferring LA-PrEP injections.
Area of Science:
- Infectious Diseases
- Pharmacology
- Public Health
Background:
- Pre-exposure prophylaxis (PrEP) is crucial for HIV prevention.
- Oral PrEP requires daily adherence, posing challenges for some users.
- Long-acting injectable PrEP (LA-PrEP) offers an alternative administration route.
Purpose of the Study:
- To assess PrEP users' preference between long-acting injectable PrEP (LA-PrEP) and oral PrEP formulations.
- To understand the primary motivations behind formulation preferences.
Main Methods:
- A cross-sectional survey was administered to 201 PrEP users in Madrid, Spain.
- Participants completed an anonymous, self-administered questionnaire regarding PrEP preferences.
- Descriptive statistics and chi-square tests were used for data analysis.
Main Results:
- Nearly 75% of participants preferred LA-PrEP, with specific preferences for subcutaneous (6-month) or intramuscular (2-month) injections.
- The main reason cited for LA-PrEP preference was practicality, including fewer clinic visits.
- Awareness of LA-PrEP formulations varied, with younger respondents (under 40) showing a greater preference for LA-PrEP.
Conclusions:
- The majority of surveyed PrEP users favor long-acting injectable formulations over oral pills.
- Increased awareness and understanding of LA-PrEP benefits could further drive adoption.
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