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Updated: May 8, 2026
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Small Bowel Transplantation In Mice
Published on: August 20, 2007
Mycotic Aneurysms in Intestinal Transplantation: A Case Series
Nicola Colucci1,2, Ivan De Gruttola1, Harry V M Spiers1,2,3
1Roy Calne Transplant Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.
Clinical Transplantation
|May 6, 2026
Summary
Mycotic aneurysms after intestinal transplantation are rare but deadly. Early detection and aggressive management, including endovascular stent grafting, are crucial for survival, though outcomes remain poor.
Area of Science:
- Gastroenterology
- Transplantation Surgery
- Vascular Surgery
Background:
- Mycotic aneurysms (MA) are a severe complication following intestinal transplantation (ITx).
- Risk factors include chronic abdominal sepsis, graft contamination, and immunosuppression.
- MA can be a life-threatening post-transplant complication.
Purpose of the Study:
- To investigate the incidence, characteristics, and outcomes of mycotic aneurysms in adult intestinal transplant recipients.
- To evaluate diagnostic methods and management strategies for MA post-ITx.
Main Methods:
- Retrospective review of a prospectively maintained database of adult ITx recipients.
- Analysis of patient data from December 2007 to June 2025.
- Review of MA episodes, including timing, diagnosis, treatment, and outcomes.
Main Results:
- Six out of 168 ITx patients (3.6%) developed eight MA episodes.
- MA occurred bimodally: early (2-8 weeks) and late (55-377 weeks) post-transplant.
- High mortality (66.6%) at initial presentation; endovascular stent grafting (ESG) and conduit resection were primary treatments.
Conclusions:
- Mycotic aneurysms in ITx are rare, frequently fatal, and associated with bowel complications.
- Diagnosis often requires angio-CT or intraoperative findings.
- Aggressive management of contamination sources and timely intervention are critical, but low incidence limits broad conclusions.
