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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: May 8, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Schlemm's Canal Development and Implications for Glaucoma Treatment.

Krishnakumar Kizhatil1, Marina Simón2, Revathi Balasubramanian2

  • 11Department of Ophthalmology and Visual Sciences, The Ohio State University Medical Center, Columbus, Ohio, USA.

Annual Review of Vision Science
|May 6, 2026
PubMed
Summary

Schlemm's canal (SC) development is key to regulating eye pressure and preventing glaucoma. Understanding SC morphogenesis and aqueous humor drainage offers new glaucoma treatment strategies.

Related Experiment Videos

Last Updated: May 8, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Vascular Biology

Background:

  • Schlemm's canal (SC) regulates intraocular pressure, crucial for preventing glaucoma.
  • SC endothelial cells form the final barrier to aqueous humor drainage.
  • SC development involves canalogenesis, mirroring blood and lymphatic vessel formation.

Purpose of the Study:

  • To review current knowledge on Schlemm's canal development and function.
  • To explore the role of SC in aqueous humor drainage and glaucoma.
  • To discuss implications for novel glaucoma treatment strategies.

Main Methods:

  • Review of recent studies on SC development.
  • Analysis of single-cell sequencing data.
  • Examination of functional morphology and aqueous humor dynamics.

Main Results:

  • SC development is coordinated with trabecular meshwork formation.
  • SC exhibits combined lymphatic and blood vascular features.
  • Single-cell sequencing advances understanding of SC development and glaucoma-associated genes.

Conclusions:

  • Incomplete understanding of SC development and drainage mechanisms persists.
  • SC plays a critical role in maintaining ocular homeostasis.
  • Further research into SC biology may yield new glaucoma therapies.