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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

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Longitudinal Lifestyle Profiles Influence Health Trajectories in Aging: Evidence from a Population-Based Sample.

Irene Brianzoni¹, Michele Rossi¹, Mauro Colombo¹

¹Golgi Cenci Foundation, Abbiategrasso, Italy.

Neuroepidemiology

|May 6, 2026

Summary

Maintaining healthy lifestyle habits like physical activity and social engagement during aging significantly benefits cognitive, mental, and physical health. These lifestyle changes are crucial for promoting healthy aging and overall well-being.

Keywords:

Group-based trajectory Health-related behaviors Healthy aging Life course Lifestyle

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Area of Science:

Gerontology
Public Health
Behavioral Science

Background:

Global population aging necessitates understanding modifiable lifestyle impacts on health.
Key health domains include cognitive, mental, and physical well-being in older adults.
Identifying distinct lifestyle profiles during aging is crucial for targeted interventions.

Purpose of the Study:

To identify distinct lifestyle habit profiles in aging adults.
To assess the impact of these profiles on cognitive, mental, and physical health.
To determine the unique contribution of each lifestyle habit to health outcomes.

Main Methods:

Longitudinal study of 966 dementia-free older adults (70-75 years) over 12 years.
Multivariate longitudinal K-means clustering analyzed six lifestyle habits.
Health outcomes assessed via cognitive, mental, and physical health measures.

Main Results:

Three distinct lifestyle profiles were identified.
The healthiest profile (Cluster B) showed superior cognitive, mental, and physical trajectories.
Physical activity, social engagement, and cognitive activity independently predicted better health.

Conclusions:

Consistent engagement in healthy behaviors during aging yields significant health benefits.
Interventions promoting healthy aging should adopt multifaceted, community-level approaches.
Lifestyle modifications are key to enhancing healthspan in older populations.