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Tandem WGSR-Inspired Nitroarene Reductive Carbonylative C-N Coupling for Nongaseous Amide Synthesis
Hongyu Yang1, Jinghui Yang1, Jiawei Wang1
1Key Laboratory of Applied Surface and Colloid Chemistry (MOE), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, P. R. China.
Abstract:
A tandem reductive carbonylation of nitroarenes with boronic acids is achieved under mild conditions (65 °C, ambient pressure), using Fe(CO)5 and H2O as a bifunctional syngas surrogate. The Fe(CO)5-mediated water-gas shift reaction (WGSR) generates hydrides for nitro reduction and supplies CO in situ for Pd-catalyzed carbonylative C-N coupling. This operationally simple protocol provides direct access to amides without external CO/H2, exhibiting broad functional group tolerance and an enhanced safety profile.
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