Alzheimer's disease with progression analysis using a novel dilated convolutional attention based long short term
Anusha Rudraraju1, S Venkata Lakshmi2
1Research Scholar, Department of CSE, GITAM School of Technology, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh 530045, India.
Psychiatry Research. Neuroimaging
|May 6, 2026
Summary
A new deep learning framework accurately detects Alzheimer's disease (AD) using EEG signals. This automated system offers high precision for early diagnosis, improving patient quality of life.
Area of Science:
- Neuroscience
- Artificial Intelligence
- Biomedical Engineering
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting cognition and behavior.
- Early detection of AD is vital for improving patient outcomes and quality of life.
- Current diagnostic methods, including manual neuroimaging analysis, are time-consuming, subjective, and prone to errors.
Purpose of the Study:
- To develop an efficient and automated deep learning framework for early Alzheimer's disease detection and progression prediction.
- To overcome limitations of traditional diagnostic approaches and existing machine learning techniques in handling complex, high-dimensional biomedical data.
Main Methods:
- Utilized the CAU-EEG dataset for Electroencephalography (EEG) signal acquisition.
- Extracted comprehensive features including time, frequency, and time-frequency domain characteristics.
- Implemented a novel deep learning model, dilated convolutions attention based long short term memory (DC-ALSTM), for classification.
Main Results:
- The proposed DC-ALSTM model demonstrated superior performance compared to existing baseline methods.
- Achieved high classification accuracy (99.26%), precision (99.21%), recall (99.23%), and F1-score (99.22%).
- The results indicate outstanding diagnostic capability for Alzheimer's disease.
Conclusions:
- The developed deep learning framework offers a highly accurate and automated solution for Alzheimer's disease diagnosis.
- The DC-ALSTM model shows significant potential for early and reliable detection of AD.
- This approach addresses the need for efficient diagnostic systems in neurodegenerative disease management.
Related Concept Videos
Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Dementia
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
The progression of dementia is generally gradual.
Alzheimer's Disease: Treatment
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

