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Updated: May 8, 2026

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety
Published on: November 11, 2022
Iron-dependent brain reshaping links social isolation to anxiety
1The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
None:
Social isolation is a rising public health threat linked to anxiety, yet its brain mechanisms remain unclear. Wang et al.1 uncover a glucocorticoid-iron-α-synuclein axis in ventral hippocampal neurons that drives maladaptive synaptic remodeling-termed "ferroplasticity"-and anxiety, pioneering new therapeutic entry points.
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