Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Behavior Therapy01:22

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shared genetic architecture of schizophrenia and Alzheimer's disease and related dementias implicates 16p11.2 and lifespan brain vulnerability.

Molecular psychiatry·2026
Same author

A study on the effects of combined DBT and STEPPS interventions for adolescents with non-suicidal self-injury: a randomized controlled trial.

Frontiers in public health·2026
Same author

Antidepressant use and worsening of non-suicidal self-injury and suicidality in bipolar disorder: A multicenter retrospective cohort study.

Psychiatry research·2026
Same author

Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study.

Frontiers in psychiatry·2026
Same author

Efficacy and safety of atomoxetine combination therapy for obstructive sleep apnea: A meta-analysis of randomized placebo-controlled trials.

Sleep medicine·2026
Same author

A hierarchical multi-scale framework for schizophrenia: integrating symptom networks, functional circuits, and molecular pathways.

Molecular psychiatry·2026

Related Experiment Video

Updated: May 8, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

Virtual Reality-Based Cue Exposure and Aversion Therapy for Alcohol Dependence: A Randomized Controlled Trial.

Haoyu Zhao1, Xiaotong Ying1, Xiaoyu Du1

  • 1The Second Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.

Addiction Biology
|May 6, 2026
PubMed
Summary
This summary is machine-generated.

Virtual reality therapy combining cue exposure and aversion therapy reduced alcohol craving and attentional bias in patients with alcohol dependence. While relapse rates did not differ, this combined VR approach shows promise beyond standard care.

Keywords:
alcohol dependenceattentional biasaversion therapycue exposure therapyvirtual reality

More Related Videos

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats
13:24

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

Published on: September 19, 2014

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

Related Experiment Videos

Last Updated: May 8, 2026

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats
13:24

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

Published on: September 19, 2014

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
05:40

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans

Published on: April 28, 2022

Area of Science:

  • Addiction Medicine
  • Psychiatry
  • Digital Health

Background:

  • Alcohol dependence (AD) has a high relapse rate, necessitating innovative treatment approaches.
  • Virtual reality (VR) offers immersive platforms for therapies like cue exposure (VR-CET) and aversion therapy (VR-AT).

Purpose of the Study:

  • To evaluate the efficacy of VR-CET, VR-AT, and their combination in treating alcohol dependence.
  • To assess impacts on craving, emotional state, sleep quality, attentional bias, and relapse rates.

Main Methods:

  • A single-center randomized controlled trial involving 80 male inpatients with AD.
  • Four groups: control, VR-CET, VR-AT, and combined VR-CET + AT, with 8 sessions over 15 days.
  • Utilized VAS, PACS, HAMD, HAMA, PSQI, and VR eye-tracking to measure outcomes; relapse assessed via telephone follow-up.

Main Results:

  • All groups showed significant improvements in craving, mood, anxiety, and sleep post-treatment.
  • The combined VR-CET + AT group demonstrated reduced alcohol-cue fixation time ratio and craving (VAS) compared to the control group.
  • No significant differences in relapse rates were observed among the groups at 4 and 12 weeks.

Conclusions:

  • Combined VR-CET and VR-AT effectively reduced craving and attentional bias in AD patients beyond standard care.
  • Further research with larger sample sizes and longer follow-up periods is needed to confirm effects on relapse rates.
  • VR therapies show potential as adjuncts in addiction treatment.