Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

iNOS is a key mediator of anti-PD-1 melanoma therapy response.

Frontiers in immunology·2026
Same author

Evaluation of the Feasibility and Safety of Ifosfamide-Based Chemotherapy Regimens for Sarcomas in the Outpatient Setting.

JCO oncology practice·2026
Same author

<b>New Middle Jurassic Osmylopsychopidae (Neuroptera) from Northeastern China</b>.

Zootaxa·2026
Same author

<b>New hemeroscopid (Odonata: Hemeroscopidae) from Lower Cretaceous Jinju Formation (South Korea) illustrating variation of wing vannal region among hemeroscopids and prohemeroscopids</b>.

Zootaxa·2026
Same author

<b>A new Jurassic neuropteran larva (Neuroptera: Osmyloidea)</b>.

Zootaxa·2026
Same author

<b>A new mid-Cretaceous Apsilocephalidae (Diptera) with elongated mouthparts from Kachin amber</b>.

Zootaxa·2026

Related Experiment Video

Updated: May 8, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Molecular Pathology of Soft-tissue Neoplasms.

Boju Pan1, Dong Ren2, Ghulam Rasool3

  • 1Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Surgical Pathology Clinics
|May 6, 2026
PubMed
Summary

Molecular pathology advances have transformed soft-tissue tumor diagnosis and treatment. Genomic alterations define subtypes, guiding targeted therapies for better patient outcomes.

Keywords:
BiomarkersGenomicsMolecular pathologySarcomaSoft tissue tumorsTargeted therapy

More Related Videos

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Related Experiment Videos

Last Updated: May 8, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Soft-tissue tumors are rare mesenchymal neoplasms with significant heterogeneity.
  • Traditional diagnosis relies on morphology, often insufficient for precise classification.

Purpose of the Study:

  • To highlight the transformative impact of molecular pathology on soft-tissue tumor diagnosis and management.
  • To discuss how genomic alterations define tumor subtypes and guide targeted therapies.

Main Methods:

  • Review of advances in molecular pathology techniques.
  • Analysis of recurrent genomic alterations (gene fusions, mutations, amplifications, epigenetic changes).
  • Integration of data from fluorescence in situ hybridization, next-generation sequencing, and methylation-based sequencing.

Main Results:

  • Molecular profiling precisely characterizes soft-tissue tumor subtypes.
  • Genomic alterations serve as biomarkers for targeted therapy selection.
  • Emerging technologies like circulating biomarkers and AI show promise.

Conclusions:

  • Molecular pathology is crucial for accurate diagnosis, prognosis, and predicting treatment response in soft-tissue tumors.
  • Continued integration of molecular and genomic data will refine patient care.
  • Future advancements will further enhance the role of molecular pathology in managing these rare neoplasms.