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Updated: May 8, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
Published on: March 25, 2020
Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing
Jia Gao1, Dong Zhu2, Jian Wang1
1Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Abstract:
Skin trauma, particularly chronic non-healing wounds, imposes significant economic and physical burdens on patients and their families. A defining feature of these wounds is persistent dysregulated inflammation, with macrophage efferocytosis playing a critical role. Efferocytosis-the programmed removal of apoptotic cells (ACs) by macrophages-is vital for resolving inflammation and facilitating tissue repair. In chronic wounds associated with systemic diseases such as diabetes, impaired macrophage efferocytosis hinders AC clearance, leading to prolonged inflammation and delayed healing. This review focuses on the molecular mechanisms regulating macrophage efferocytosis during inflammation and discusses clinical strategies to improve the healing of chronic wounds.
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