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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Treatment and Outcomes for Acute Ischemic Stroke in Cardiomyopathy Patients With Heart Failure: A Retrospective

Aarti Kishore Jain1,2, Nimrod Gozum1,2, Serena Wong3

  • 1From the School of Medicine, New York Medical College, Valhalla, NY.

Cardiology in Review
|May 7, 2026
PubMed

Insights

Cardiomyopathy and heart failure patients with acute ischemic stroke receive advanced stroke interventions, including endovascular thrombectomy, at higher rates. Survivors show improved discharge outcomes, indicating treatment safety and efficacy.

Area of Science:

  • Neurology
  • Cardiology
  • Public Health

Background:

  • Cardiomyopathy (CM) and heart failure (HF) significantly increase stroke risk.
  • Acute ischemic stroke (AIS) in patients with CM and HF presents unique challenges.
  • Understanding treatment patterns and outcomes in this population is crucial for improving care.

Purpose of the Study:

  • To examine the incidence of reperfusion therapies (intravascular thrombolysis, endovascular thrombectomy) in AIS patients with CM and HF.
  • To compare functional outcomes, complications, and mortality between AIS patients with and without CM/HF.
  • To assess the safety and efficacy of stroke interventions in patients with concomitant CM and HF.

Main Methods:

  • Retrospective analysis of the National Inpatient Sample database (2016-2019).
  • Identification of AIS patients with and without concurrent CM and HF using ICD-10 codes.
  • Propensity score matching and multivariable logistic regression for comparative analysis.

Main Results:

  • AIS patients with CM and HF (2.8% of cohort) experienced more severe strokes.
  • Higher rates of endovascular thrombectomy (8.8% vs 5.6%) were observed in CM/HF patients.
  • CM/HF patients had increased inpatient mortality (6.6% vs 5.4%) but more favorable discharge dispositions upon survival (45.7% vs 43.9%).

Conclusions:

  • Stroke interventions, particularly endovascular thrombectomy, are utilized more frequently in AIS patients with CM and HF.
  • While associated with higher mortality risk, surviving CM/HF patients demonstrate better discharge outcomes.
  • Stroke intervention appears safe and efficacious in patients with CM and HF, despite increased baseline risks.

Keywords:
cardiomyopathyheart failureintravenous thrombolysisischemic strokethrombectomy

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