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Related Experiment Video

Updated: May 8, 2026

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice

Published on: June 22, 2021

Recent advances in TMEM16F: structural plasticity, functional versatility, and implications for human diseases.

Li Chen¹, Zhigang Qian²

¹Material Supply Center, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

Cell Communication and Signaling : CCS

|May 7, 2026

Summary

This review details the calcium-activated membrane protein TMEM16F, a phospholipid scramblase and ion channel. It explores TMEM16F

Keywords:

Blood coagulation Cell fusion Inflammation Ion channel Neurodegenerative diseases Phospholipid scramblase Structural mechanisms TMEM16F Tumor immunity

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Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

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Last Updated: May 8, 2026

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice

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Published on: June 22, 2021

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

Area of Science:

Molecular Biology
Cell Biology
Biochemistry

Background:

TMEM16F is a calcium-activated membrane protein with dual functions as an ion channel and phospholipid scramblase.
It plays a critical role in linking intracellular calcium signaling to plasma membrane lipid asymmetry.
Recent advances have elucidated TMEM16F's structure, conformational heterogeneity, and allosteric regulation by Ca²⁺, pH, and membrane environment.

Purpose of the Study:

To provide a comprehensive overview of TMEM16F biology, integrating recent structural, cellular, and pathological findings.
To highlight the mechanisms underlying TMEM16F's dual functions.
To summarize emerging evidence for TMEM16F's roles in physiological processes and disease pathogenesis.

Main Methods:

Literature review integrating structural biology, cell biology, and disease pathology studies.
Analysis of cell- and tissue-specific data on TMEM16F function.
Synthesis of information on TMEM16F regulation and its involvement in physiological and pathological conditions.

Main Results:

TMEM16F exhibits significant conformational heterogeneity and is allosterically regulated.
Membrane remodeling by TMEM16F is crucial for blood coagulation, cell fusion, cell death, immune responses, and neurodevelopment.
Dysregulation of TMEM16F is implicated in bleeding disorders, thromboinflammation, neurodegeneration, infections, and cancer.

Conclusions:

TMEM16F's dual functions are coordinated through complex regulatory mechanisms involving calcium, pH, and membrane context.
TMEM16F-mediated membrane dynamics are essential for numerous physiological processes.
Aberrant TMEM16F activity contributes to a wide range of human diseases, presenting potential therapeutic targets.