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Updated: May 8, 2026

Single Molecule Fluorescence Microscopy on Planar Supported Bilayers
Published on: October 31, 2015
Rapid assembly of fluorescence enhanced plasmonic dimers for intracellular single-particle imaging
Yang Zhou1, Fengju Shen1, Qirong Zou1
1State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlzhang@njupt.edu.cn.
Abstract:
Fluorescence enhanced plasmonic dimers were successfully synthesized from assembled gold nanoparticles and coated with a silica shell of different thicknesses with yields around 70%, and then the fluorescence enhancement of Cy5 adsorbed on their surface was adjusted by controlling the coated SiO2 shell thickness. In situ cellular confocal imaging of this dimer fluorescent probe achieved about 9-fold enhancement which matched with the simulation calculations.

