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Simple and Rapid Method to Obtain High-quality Tumor DNA from Clinical-pathological Specimens Using Touch Imprint Cytology
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Tumour acquisition method and molecular profiling success in advanced cholangiocarcinoma

Eleni Vrana1, Alia Alothman2, Luke Taylor1

  • 1The Christie NHS Foundation Trust, Manchester, UK.

Acta Oncologica (Stockholm, Sweden)
|May 7, 2026
PubMed
Abstract

No abstract available in PubMed .

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...