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Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Polygenic Traits01:18

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

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Updated: May 8, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

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Published on: June 2, 2015

Harnessing Polygenic Risk Scores to Refine Venous Thromboembolism Risk Stratification.

Katlyn G McKay1, Oliver S Zhao2, Samaya S Badrieh3

  • 1Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

European Journal of Haematology
|May 7, 2026
PubMed
Summary
This summary is machine-generated.

Polygenic risk scores (PRS) significantly increase the odds of venous thromboembolism (VTE) in both adults and children. PRS can help stratify VTE risk alongside traditional clinical factors.

Keywords:
genetic variantspolygenic risk scorevenous thromboembolism

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Last Updated: May 8, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Published on: February 10, 2023

Area of Science:

  • Genetics and genomics
  • Cardiovascular medicine
  • Pediatric medicine

Background:

  • Venous thromboembolism (VTE) is a significant cause of illness across all age groups.
  • The role of polygenic risk scores (PRS) in VTE susceptibility requires further investigation.
  • This study assesses the independent contribution of PRS to VTE risk in adults and children.

Purpose of the Study:

  • To evaluate the independent impact of a polygenic risk score (PRS) on venous thromboembolism (VTE) susceptibility.
  • To compare the effectiveness of PRS in predicting VTE in adult and pediatric populations.
  • To identify key clinical risk factors associated with VTE in both age groups.

Main Methods:

  • A retrospective case-control study was conducted using two distinct cohorts (adults and children).
  • Three VTE PRS models were evaluated, with a primary focus on a 293 single nucleotide polymorphism (SNP) PRS.
  • Multivariable logistic regression analyses were performed to assess the association between risk factors and VTE in adults and children.

Main Results:

  • A higher PRS was significantly associated with increased VTE odds in adults (OR=1.25 per SD increase).
  • Key adult VTE risk factors included cancer (OR=2.43) and recent surgery (OR=2.16).
  • The PRS also indicated increased VTE risk in children (OR=1.38), with central venous catheterization being the foremost risk factor (OR=5.65).

Conclusions:

  • VTE in both adults and children is multifactorial, influenced by both clinical and genomic factors.
  • Polygenic risk scores show promise as a valuable tool for VTE risk stratification.
  • Integrating PRS with clinical risk factors may enhance the accuracy of VTE risk assessment.