Related Experiment Video

Updated: May 8, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
13:51

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

Published on: November 11, 2018

Rho GTPases in cancer resistance: mechanisms, vulnerabilities, and therapeutic opportunities

Amy Beaudin1,2,3,4, Philippe Lefrançois5,6,7, Mélanie Laurin1,2,3,4

  • 1Département de biologie moléculaire, biochimie médicale et pathologie, Faculté de médecine, Université Laval, Québec, QC, Canada.

Biochemical Society Transactions
|May 7, 2026
PubMed

Insights

Rho GTPase signalling networks are key regulators of cancer therapy resistance. Targeting these pathways offers a promising strategy for developing next-generation cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Intrinsic and adaptive resistance to cancer therapy are significant obstacles.
  • Mechanisms of resistance, including epithelial-mesenchymal transition and metabolic reprogramming, are linked to Rho GTPase signalling.
  • Rho GTPase pathways are central regulators of therapeutic resistance across various cancer types.

Purpose of the Study:

  • To review recent findings on Rho GTPase signalling in cancer therapy resistance.
  • To evaluate emerging strategies targeting Rho GTPase signalling axes.
  • To discuss the clinical applicability of targeting Rho GTPase pathways.

Main Methods:

  • Literature review of experimental findings.
  • Synthesis of recent research linking Rho GTPase signalling to therapy resistance.
  • Critical examination of therapeutic strategies targeting Rho GTPase pathways.

Main Results:

  • Rho GTPase signalling networks are integrated with diverse cancer resistance mechanisms.
  • These pathways are identified as central regulators of therapeutic resistance.
  • Emerging strategies focus on inhibiting Rho GTPases, their effectors, or regulators like RhoGEFs and RhoGAPs.

Conclusions:

  • Targeting Rho GTPase signalling holds significant therapeutic potential for cancer.
  • Developing strategies to modulate Rho GTPase pathways is crucial for next-generation cancer treatments.
  • Challenges and opportunities exist for the clinical deployment of these targeted approaches.
Keywords:
Rho GTPasecancerchemotherapy resistancesignallingsmall moleculestreatment resistance

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