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Updated: May 8, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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TMPRSS2-ERG Fusion Identified by Comprehensive Genomic Profiling Reveals Prostatic Origin in Cancer of Unknown

Koji Hikino1, Wataru Naito2, Shinichi Teshima2

  • 1Department of Clinical Oncology, Shonan Kamakura General Hospital, Kamakura, JPN.

Cureus
|May 7, 2026
PubMed
Summary

Comprehensive genomic profiling aids in identifying the origin of cancer of unknown primary (CUP). This approach detected a TMPRSS2-ERG fusion, confirming prostate cancer in a patient with metastatic disease.

Keywords:
cancer of unknown primarycomprehensive genomic profilinggene fusionlymph node metastasismolecular diagnosisprostate cancertissue of origintmprss2-erg fusion

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