Left ventricular myocardial work and its determinants in healthy subjects and the possible potential correlation with...

This study aimed to investigate the effects of gender, age and other physiologic parameters on left ventricular (LV) myocardial work (MW) in healthy subjects and to explore the potential correlation between the MW and the ventricular myocardial band (VMB).

According to the inclusion criteria 479 subjects aged ≥20 years old who visited our hospital from September 2019 to August 2022 were enrolled and were divided into three groups by 15 years as the age interval. Among them, 187 were 20-39 years old {(39.04%), including 87 men (46.52%) and 100 women (53.47%)}; 153 were 40-54 years old {(31.94%), including 63 men (41.18%) and 90 women (58.82%)}; 139 were aged ≥55 years {(29.02%), including 75 men (53.96%) and 64 women (46.04%)}. All subjects underwent echocardiography and apical views were analyzed. Blood pressure (BP) was measured after the examination.

MW exhibited distinct gender- and age-specific characteristics. Within the same age group, females demonstrated higher MW values than males. Furthermore, a significant age-related decline in MW was observed in females, particularly after 55 years of age. Additionally, the distribution patterns of MW, especially active work, suggested a potential correlation with the VMB.

1. MW evaluating by using echocardiography may be a good method for the assessment of real time, quantitative global and regional MW and the MW has obvious gender and age characteristics.2. There is a certain potential correlation between the MW and the VMB.