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Polymorphism engineering of mefenamic acid for enhanced pharmacokinetic performance

Parteek Prasher1, Mousmee Sharma2

  • 1Department of Chemistry, University of Petroleum & Energy Studies (UPES), Dehradun, 248007, India.

EXCLI Journal
|May 7, 2026
PubMed

Insights

Mefenamic acid co-crystals, guided by its polymorphic forms, offer improved bioavailability over other methods. Rational design is key for clinical translation and overcoming solubility challenges.

Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry
  • Drug Delivery

Background:

  • Mefenamic acid, a BCS Class II drug, exhibits poor solubility and variable absorption, leading to frequent dosing and ulcerogenicity.
  • Current advanced formulation strategies like hydrotropy, nanosizing, and complexation have limitations.
  • Polymorphism-driven co-crystallization presents a promising alternative for enhancing mefenamic acid bioavailability.

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