Related Experiment Videos
Cumulative Triglyceride-Glucose Index and Risk of Metabolic Dysfunction-Associated Fatty Liver Disease: Findings from
Chao Zhang1, Zixin Zhang2,3, Qi Qi2,3
1Catheterization Unit, Tangshan Gongren Hospital, Tangshan, People's Republic of China.
Purpose:
This study aimed to investigate the relationship between the cumulative triglyceride-glucose (cum-TyG) index and the risk of new-onset metabolic dysfunction-associated fatty liver disease (MAFLD).
Patients And Methods:
The present study involved 89,831 participants selected from the Kailuan cohort. The cum-TyG index was evaluated by determining the weighted average of TyG index values recorded at each visit. Participants were divided into four groups based on the quartiles of cum-TyG index or the duration of high TyG index exposure. To investigate the association between levels of the cum-TyG index and the risk of new-onset MAFLD, Cox proportional hazards regression analysis was performed.
Results:
A total of 16,387 cases of new-onset MAFLD were recorded over a median follow-up duration of 10 years. The Cox proportional hazards regression analysis indicated that the hazard ratios (HRs) and 95% confidence intervals (CIs) significantly increased in quartile 2 (HR: 1.306, 95% CI: 1.246-1.367), quartile 3 (HR: 1.423, 95% CI: 1.357-1.492), and quartile 4 (HR: 1.648, 95% CI: 1.571-1.730), when compared to quartile 1. A similar pattern was noted for 2-year high TyG index exposure (HR: 1.267, 95% CI: 1.200-1.338), 4-year high TyG index exposure (HR: 1.642, 95% CI: 1.557-1.731), and 6-year high TyG index exposure (HR: 2.122, 95% CI: 2.010-2.239), when compared to 0-year high TyG index exposure.
Conclusion:
The cum-TyG index may provide important information for risk assessment of MAFLD.
Related Concept Videos
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Type II Diabetes I: Introduction
Type II Diabetes II: Pathophysiology
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...