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Updated: May 8, 2026

A Mouse Model of Fatigue Induced by Peripheral Irradiation

A Mouse Model of Fatigue Induced by Peripheral Irradiation

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A mouse model to study persistent fatigue.

Adam J Janowski¹, Kazuhiro Hayashi¹, Ashley N Plumb¹

¹University of Iowa.

Research Square

|May 7, 2026

Summary

This summary is machine-generated.

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Researchers developed a mouse model for persistent fatigue, a common chronic illness symptom. This model helps investigate fatigue mechanisms and potential treatments by observing behavioral and immune changes.

Area of Science:

Immunology
Metabolic studies
Neuroscience

Background:

Fatigue is a debilitating symptom common in chronic illnesses, significantly impacting daily life.
Limited animal models hinder the understanding of fatigue's underlying mechanisms and the development of effective therapies.

Purpose of the Study:

To develop a novel mouse model for inducing persistent fatigue-like behaviors.
To characterize behavioral, immune, and metabolic changes associated with this fatigue model.
To explore potential therapeutic strategies by understanding fatigue mechanisms.

Main Methods:

Induction of fatigue-like behaviors using a combination of acute stress and lipopolysaccharide (LPS) or saline.
Assessment of physical fatigue through voluntary wheel running and open field tests.

Keywords:

Fatigue immune system metabolomics open field running wheel

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

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Related Experiment Videos

Last Updated: May 8, 2026

A Mouse Model of Fatigue Induced by Peripheral Irradiation

A Mouse Model of Fatigue Induced by Peripheral Irradiation

Published on: March 17, 2017

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Evaluation of pain sensitivity, immune cell phenotype, and plasma metabolite profiles.

Main Results:

Combined acute stress and LPS effectively induced long-lasting fatigue-like behaviors.
Key findings included a reduced T-helper to T-cytotoxic cell ratio and altered fatty acid metabolites post-induction.
Specific stressors influenced the observed mechanistic changes, highlighting distinct pathways.

Conclusions:

Two distinct, multi-stressor methods were established to create persistent fatigue-like behaviors in mice.
These models offer valuable tools for exploring the immunological and metabolic underpinnings of fatigue.
Further research using these models can advance the development of targeted fatigue treatments.