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Related Experiment Video

Updated: May 8, 2026

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
09:44

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Published on: June 2, 2019

Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression.

Hannah L Combs1,2, Ryan Kurth3, Anuprita Nair3

  • 1Department of Neurology, Baylor College of Medicine, Houston, TX.

Medrxiv : the Preprint Server for Health Sciences
|May 7, 2026
PubMed
Summary
This summary is machine-generated.

Intraindividual variability in cognitive tasks (IIV-D) can identify early neuronal synuclein disease (NSD) and predict its progression. This cognitive marker, specifically the coefficient of variation (CoV), shows promise for early detection strategies.

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Last Updated: May 8, 2026

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Published on: May 30, 2015

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Neurology

Background:

  • Neuronal synuclein disease (NSD) is characterized by alpha-synuclein pathology and often dopaminergic dysfunction.
  • Prodromal NSD stages (2A and 2B) show subtle clinical signs without functional impairment.
  • Intraindividual variability/dispersion (IIV-D) across cognitive tasks is a potential early marker for neurodegeneration.

Purpose of the Study:

  • To determine if IIV-D distinguishes NSD Stage 2 participants from healthy controls.
  • To assess if IIV-D predicts progression to later NSD stages.

Main Methods:

  • Analysis of 934 participants (832 Stage 2 NSD, 102 controls) from the Parkinson's Progression Markers Initiative.
  • Quantification of IIV-D using total coefficient of variation (CoV) and attention/executive CoV across 11 neuropsychological tests.
  • Group comparisons and logistic regression to evaluate associations between IIV-D, clinical factors, and disease progression.

Main Results:

  • Stage 2 participants showed significantly higher CoV than controls (p = .003).
  • Elevated IIV-D correlated with worse motor symptoms, non-motor burden, and functional impairment.
  • Higher baseline CoV predicted conversion to Stage 3+ NSD within one year (OR = 1.44, p = .008), independent of motor severity.

Conclusions:

  • IIV-D, particularly CoV, serves as a sensitive cognitive marker for early NSD.
  • Cognitive dispersion metrics can predict short-term disease progression in NSD.
  • Integrating IIV-D into early detection strategies for prodromal synucleinopathies is recommended, pending further validation.