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Updated: May 8, 2026
An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
Published on: April 17, 2020
The validity of the AEON™ stapler in gastrointestinal surgery: early clinical experience and translational rationale
Aali J Sheen1,2
1Spire Hospital, Manchester, United Kingdom.
Background/Need:
Gastrointestinal stapling continues to be limited by bleeding, variable compression and leak-related morbidity, especially in bariatric and hepatopancreatobiliary (HPB) surgery. The AEON™ stapler was developed to improve uniformity of compression and staple formation.
Methodology And Device Description:
AEON™ uses an S3 (sustained, smooth and stable) compression mechanism to reduce tissue shear and optimise B-shaped staple formation. Evidence comes from a randomised controlled trial in sleeve gastrectomy, a large bariatric cohort and observational HPB series.
Preliminary Results:
Across 1, 848 bariatric cases, only one staple-line leak occurred, and 428 consecutive AEON™ cases had no stapler-related complications. A sleeve gastrectomy trial showed significantly reduced intraoperative bleeding. In a 250-patient comparison, reinforcement was required in 16.8% of AEON™ cases versus 100% using a tri-staple device. Distal pancreatectomy with AEON™ showed a pancreatic fistula rate of 20% compared with 65% for traditional staplers, and major hepatectomy was completed without transfusion in any AEON™ case.
Current Status:
AEON™ is in active clinical use with early results supporting improved haemostasis and postoperative outcomes. Larger prospective studies are underway.
