Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing Wheat Grain Safety via Chelated Iron Fertilizer-Induced Iron Turnover and Cadmium Immobilization in Alkaline Soils.

Environmental science & technology·2026
Same author

First-Line Disitamab Vedotin, Tislelizumab, and S-1 in HER2-Overexpressing Advanced Gastric or Gastroesophageal Junction Adenocarcinoma: A Single-Arm, Phase II Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Cultivation enhances warming sensitivity of redox-driven carbon pulses in black soils: The overlooked role of anaerobic legacy effects.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Ratiometric Mycotoxin Detection in Living Plants With Dual-Emissive Nanosensors.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathway.

Redox report : communications in free radical research·2026
Same author

Long term survival with trastuzumab deruxtecan for heavily pretreated, HER2 mutated advanced non-small cell lung cancer.

Discover oncology·2026
Same journal

Comprehensive proteomic analysis reveals SPRR3 as an early predictive biomarker for postoperative recurrence in pediatric chronic rhinosinusitis with nasal polyps.

The World Allergy Organization journal·2026
Same journal

Sebetralstat for on-demand treatment of hereditary angioedema: A pooled analysis of placebo-controlled clinical trials.

The World Allergy Organization journal·2026
Same journal

Long-term prophylaxis in hereditary angioedema: Real-world treatment patterns and healthcare resource utilization.

The World Allergy Organization journal·2026
Same journal

Erratum to "World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines update - IV - A quality appraisal with the AGREE II instrument" [World Allergy Organ J 15(2) (February 2022) 100613].

The World Allergy Organization journal·2026
Same journal

Why physicians underuse patient-reported outcomes in atopic dermatitis and chronic urticaria - Insights from the UCARE/ADCARE PROMUSE study.

The World Allergy Organization journal·2026
Same journal

Prevalence of allergic diseases and evaluation of total IgE and blood eosinophils as diagnostic biomarkers in Colombia, a tropical country.

The World Allergy Organization journal·2026
See all related articles

Related Experiment Videos

Integrated transcriptomic analysis identifies tsRNA-mRNA regulatory axis in asthma pathogenesis.

Ying Zhou1, Hang Lin2, Dongmei Zhou3

  • 1Department of Pediatrics Laboratory, The Affiliated Children's Hospital of Jiangnan University, Wuxi 214023, China.

The World Allergy Organization Journal
|May 7, 2026
PubMed
Summary
This summary is machine-generated.

This study reveals tRNA-derived small RNAs (tsRNAs) play a role in asthma by regulating gene expression in bronchial cells. These tsRNAs and their targets may offer new diagnostic and therapeutic avenues for asthma.

Keywords:
AsthmaBiomarkersBronchial epithelial cellsmRNAtsRNA

Related Experiment Videos

Area of Science:

  • Molecular Biology
  • Genomics
  • Respiratory Medicine

Background:

  • Asthma pathogenesis involves complex, not fully understood, molecular mechanisms.
  • tRNA-derived small RNAs (tsRNAs) are a newly identified class of non-coding RNAs with roles in various diseases.
  • The specific involvement of tsRNAs in asthma pathogenesis is largely unexplored.

Purpose of the Study:

  • To investigate the role of tsRNAs in the molecular mechanisms of asthma.
  • To identify differentially expressed tsRNAs and their target messenger RNAs (mRNAs) in asthma.
  • To construct a tsRNA-mRNA regulatory network to understand post-transcriptional regulation in asthma.

Main Methods:

  • Integrated analysis of tsRNA and mRNA profiles from severe asthma patients and healthy controls.
  • Identification of differentially expressed tsRNAs and mRNAs using MINTmap, DESeq2, miRanda, and TargetScan.
  • Validation in an independent cohort and experimental confirmation in house dust mite-stimulated bronchial epithelial cells.

Main Results:

  • Identified 58 dysregulated tsRNAs and 961 differentially expressed mRNAs in asthma.
  • Constructed a regulatory network revealing 343 tsRNA-mRNA pairs, with 36 hub mRNAs validated.
  • Confirmed the dysregulation of three candidate tsRNAs and the direct suppression of MYBL1 by tRF-21-Z4NY2V7KE.

Conclusions:

  • This study presents the first comprehensive tsRNA-mRNA regulatory network in asthma.
  • Uncovered novel post-transcriptional regulatory mechanisms in bronchial epithelial cells relevant to asthma.
  • Identified potential tsRNA biomarkers and therapeutic targets for asthma.