Elevated serum sortilin reflects inflammatory burden and coagulation dysfunction in ulcerative colitis.

Area of Science:

• Gastroenterology
• Immunology
• Biochemistry

Background:

• Sortilin, a receptor involved in inflammatory signaling, has an unclear clinical role in ulcerative colitis (UC).
• Understanding sortilin's role may offer new insights into UC pathogenesis and potential therapeutic targets.

Purpose of the Study:

• To investigate serum sortilin levels in UC patients.
• To assess the association between sortilin levels and UC disease activity, inflammation, and coagulation status.

Main Methods:

• Serum sortilin, inflammatory cytokines, and coagulation markers were measured in UC patients and healthy controls.
• Patients were categorized by disease activity and severity.
• Correlations and diagnostic accuracy (ROC analysis) of sortilin were evaluated.

Main Results:

• Serum sortilin was significantly higher in UC patients, especially those with active disease, and increased with severity.
• Sortilin levels positively correlated with inflammatory markers (CRP, TNF-α, IL-1β, IL-6, IL-17A) and coagulation indices (fibrinogen, D-dimer).
• Sortilin demonstrated high diagnostic accuracy for UC detection and severity assessment.

Conclusions:

• Elevated serum sortilin is linked to disease activity and inflammation in UC.
• Sortilin may serve as a novel biomarker for UC, indicating both inflammatory and hypercoagulable states.
• Further research into sortilin's role could inform UC management strategies.